The RhoGEF protein Plekhg5 regulates apical constriction of bottle cells during gastrulation
نویسندگان
چکیده
منابع مشابه
Endocytosis Is Required for Efficient Apical Constriction during Xenopus Gastrulation
Coordinated apical constriction (AC) in epithelial sheets drives tissue invagination [1, 2] and is required for diverse morphogenetic movements such as gastrulation [3], neurulation [4, 5], and organogenesis [6]. We showed previously that actomyosin contractility drives AC in Xenopus laevis bottle cells [7]; however, it remained unclear whether it does so in concert with other processes. Here w...
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During gastrulation in Drosophila melanogaster, coordinated apical constriction of the cellular surface drives invagination of the mesoderm anlage. Forces generated by the cortical cytoskeletal network have a pivotal role in this cellular shape change. Here, we show that the organisation of cortical actin is essential for stabilisation of the cellular surface against contraction. We found that ...
متن کاملLulu Regulates Shroom-Induced Apical Constriction during Neural Tube Closure
Apical constriction is an essential cell behavior during neural tube closure, but its underlying mechanisms are not fully understood. Lulu, or EPB4.1l5, is a FERM domain protein that has been implicated in apical constriction and actomyosin contractility in mouse embryos and cultured cells. Interference with the function of Lulu in Xenopus embryos by a specific antisense morpholino oligonucleot...
متن کاملGastrulation: PARtaking of the Bottle
Gastrulation in C. elegans embryos involves ingression of individual cells, but is driven by apical constriction of the kind that promotes migration of epithelial cell sheets. Recent work shows that PAR proteins, known for their role in polarization and unequal cell division, are also associated with the polarization that establishes this apical constriction.
متن کاملThe behaviour and function of bottle cells during gastrulation of Xenopus laevis.
The behaviour of bottle cells in normal and microsurgically altered gastrulae and in cultured explants of Xenopus laevis was analysed, using time-lapse micrography, scanning electron microscopy (SEM) and cell tracing with fluorescein dextran amine (FDA). The results shed new light on the function of bottle cells. Bottle cells forming in vivo show a predominantly animal-vegetal apical contractio...
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ژورنال
عنوان ژورنال: Development
سال: 2018
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.168922